Why acei for diabetes

Important Phone Numbers. Topic Contents Introduction Examples Possible side effects What to know about taking this medicine Where can you learn more? Top of the page. Your risk of problems from diabetes goes up when you have high blood pressure.

Prevent or slow kidney damage. Diabetes can damage the blood vessels in the kidneys. High blood pressure can damage the kidneys, too. Lower the risks of stroke and heart attack. Your risks go up when you have high blood pressure, heart disease, or both. Examples ACE inhibitors include: Benazepril. ARBs include: Irbesartan.

Possible side effects All medicines can cause side effects. Some side effects of ACE inhibitors include: Low blood pressure. You may feel dizzy and weak. A cough. High potassium levels. Swelling of your lips, tongue, or face. Diabetes is associated with both premature cardiovascular disease and renal disease. The presence of microalbuminuria is itself an independent risk factor for the development of cardiovascular disease.

Angiotensin-converting enzyme ACE inhibitors were initially shown to slow the progression of established renal disease in patients with type 1 diabetes. Subsequent trials have demonstrated a similar benefit in patients with type 2 diabetes and with the use of angiotensin II receptor blockers ARBs. These benefits were maintained within the diabetic subgroups of these trials and appear to be independent of blood pressure lowering.

The LIFE trial also provides evidence of the benefits of ARBs in reducing cardiovascular events in a high-risk population of diabetic patients with hypertension and left ventricular hypertrophy. Ideally, therefore, all diabetic patients with renal or cardiovascular disease should be treated with ACE inhibitors or ARBs. The complete database of evidence-based questions and answers is copyrighted by FPIN.

This series is coordinated by John E. Delzell Jr. Want to use this article elsewhere? Get Permissions. Read the Issue. Sign Up Now. Previous: Intimate Partner Violence. Oct 15, Issue. Clinical Question Does therapy with angiotensin-converting enzyme ACE inhibitors or angiotensin receptor blockers ARBs prevent progression to chronic kidney disease CKD in normotensive patients with microalbuminuria? Evidence-Based Answer ACE inhibitors reduce the risk of progression to macroalbuminuria in normotensive patients with microalbuminuria and type 1 diabetes mellitus.

Enlarge Print Table 1. Table 1. Recommendations from Others The Kidney Disease: Improving Global Outcomes guideline recommends ARBs or ACE inhibitors for adults with CKD with or without diabetes who have a urinary albumin excretion rate of 30 to mg per 24 hours and in whom blood pressure medications are indicated.

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