Can you take lyrica and cymbalta together

Risk Summary: There are no adequate and well-controlled studies in pregnant women; animal reproduction studies have shown increased incidences of fetal structural abnormalities and other manifestations of developmental toxicity. Comment: -Patients should be advised of the potential risk to a fetus. Increased incidences of fetal structural abnormalities and other manifestations of developmental toxicity including skeletal malformations, retarded ossification, and decreased fetal body weight have been observed in rat and rabbit offspring receiving this drug at 18 times or greater the maximum recommended dose during organogenesis.

Lethality, growth retardation, and nervous and reproductive system functional impairment have been observed in rat offspring receiving this drug during gestation and lactation.

Rat offspring tested as adults, showed neurobehavioral abnormalities decreased auditory startle responding. Adverse reproductive and developmental effects have been observed in male rats.

To provide information regarding the effects of in utero exposure to this drug, physicians are advised to recommend that pregnant patients enroll in the North American Antiepileptic Drug NAAED Pregnancy Registry. This can be done by calling the toll free number , and must be done by patients themselves. Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Comments: -Some experts state that a more thoroughly studied alternative agent e. Comment: -Because of the potential risk of tumorigenicity, breastfeeding is not recommended during treatment. An unexpectedly high incidence of hemangiosarcoma was observed in standard preclinical in vivo lifetime carcinogenicity studies in 2 different strains of mice.

The clinical significance of this finding is unknown. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Switch to: Professional Interactions. These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine.

Always consult your healthcare provider before starting or stopping any medication. Disclaimer: This content should not be considered complete and should not be used in place of a call or visit to a healthcare professional.

Medication List Close Cymbalta Lyrica. Show 7 interactions. The following applies to the ingredients: Duloxetine found in Cymbalta and Pregabalin found in Lyrica Treatment with DULoxetine may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with pregabalin can increase that risk.

Close all sections. The following applies to the ingredients: Duloxetine found in Cymbalta DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. The following applies to the ingredients: Pregabalin found in Lyrica Alcohol can increase the nervous system side effects of pregabalin such as dizziness, drowsiness, and difficulty concentrating.

Open all sections. Fibromyalgia was initially thought to be a musculoskeletal disorder, but research now suggests it's a disorder of the central nervous system - the brain and spinal cord. Researchers believe that fibromyalgia amplifies painful sensations by affecting the level and activity of brain chemicals responsible for processing pain signals. It affects twice as many women as men. Pain News Network is a c 3 non-profit online news service for information and commentary about chronic pain and pain management.

Our mission is to raise awareness, connect and educate pain sufferers, caregivers, healthcare providers and the public about the pain experience. Pain News Network is a c 3 nonprofit charity. Contributions are tax deductible for U. This website is for informational purposes only and should not be considered as medical advice, diagnosis or treatment.

Always seek the advice of a physician or healthcare provider for any questions you may have regarding a medical condition. But, Dr. Gilron notes, the vast majority of patients who reported moderate to severe drowsiness 27 percent of all patients stayed in the trial.

Says Dr. But that means three-quarters did not. I also think it is telling that people decided to keep taking the drugs, because if they thought that the benefit of the drug was not worth the side effects they likely would have dropped out of the study.

Talk with your doctor about the right treatment approach for you. If your current medication is working well there may be no reason to make a change. For those patients, combination therapy may be the right approach. Fibromyalgia medications work best when used along with non-drug treatment approaches, especially exercise, experts say.

Acupuncture, meditative movement and cognitive behavioral therapy may also provide some benefit.